3rd All Hands Meeting 2022
Structured Tandem Repeat Proteins in the era of highly accurate structure prediction

About

The REFRACT consortium is happy to invite you to the event Structured Tandem Repeat Proteins in the era of high accurate structure prediction, to be held in Padova on 5-7 October 2022.

The AlphaFold revolution led to a significant increase in the number of accurate protein structures available. Currently, the PDB contains less than 200’000 structures, obtained by different experimental techniques. Such PDB entries correspond to about 50’000 UniProt sequences. Meanwhile, AlphaFoldDB contains over 200 million protein predicted structures, covering the whole UniProt. The availability of new structural data allows not only the identification and classification of Structural Tandem Repeats in Proteins but also the discovery of new folds and functions associated with them. This event will cover the recent advances in Tandem Repeat Proteins identification, classification and functional characterization.

Hackathon

A one-day workshop open to all consortium members and invited guests.

REFRACT Supervisory Board

Closed-door meeting for REFRACT SB members to discuss internal management and science.

Structured Tandem Repeat Proteins in the era of high accurate structure prediction

A two-day symposium with a focus on tandem repeat proteins, including speeches delivered by REFRACT PIs and other invited guests. The conference features an ESRs' symposium. Open to interested public.

Program

REFRACT Conference on Structured Tandem Repeat Proteins in the era of high accurate structure prediction

6 October, Thursday 9:30-17:30

Aula Magna Lepschy, Department of Information Engineering

9:00 - 9:30

Registration

9:30 - 9:35

Silvio Tosatto
Welcome Note

9:35 - 9:50

Paula Arrías
Ongoing efforts towards an entirely manually curated RepeatsDB

9:50 - 10:05

Patricio Chinestrad
Rational design of new allosteric inhibitors for the enzyme IDO1, based on the stabilization of inactive conformations

10:05 - 10:20

Mariane Goncalves
Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered

10:20 - 10:35

Ruben Garcia Dominguez
Protein architectures and Repeats: Key of complexity growth in evolution?

10:35 - 10:50

Rubiel Vargas-Canas
NLP offers tandem repeats case-finding for structure labeling

10:50 - 11:20

Coffee break

11:20 - 11:35

Damian Bertoni
TBC

11:35 - 11:50

Feifei Xia
Uncovering the role of short tandem repeats in colorectal cancer

11:50 - 12:05

Ian Czarnowski
Characterization of the action mechanism of a new class of inhibitors for the pyruvate kinase M2(PKM2) enzyme with potential antitumoral activity

12:05 - 12:20

Leticia Ferrelli
Identification of Membrane Coat-like associated proteins in PVC superphylum

12:20 - 12:35

Damiano Clementel
RepeatsDB 2023

12:35 - 14:30

Lunch

14:30 - 15:05

Andrey Kajava
In search of new folds in AlphaFold models of proteins with repeats

15:05 - 15:40

Miguel Andrade
Tandem repeats in giant viruses

15:40 - 16:10

Coffee break

16:10 - 16:45

Sara Chuguransky
Repeats curation in Pfam. Building repeats in Pfam and AlphaFold guidance

16:45 - 17:20

Néstor Díaz
Classifying Elongated TRPs using Fractal and Complexity measures

17:20 - 17:30

Wrap up and discussion

7 October, Friday 9:00-13:00

Aula Magna Lepschy, Department of Information Engineering

9:00 - 9:30

Welcome Desk

9:30 - 10:05

Damien Devos
PVC bacteria, microbiology’s platypus and TRPs

10:05 - 10:40

Layla Hirsh
Bioinformatic tools for the curation and prediction of repeat protein families

11:40 - 11:10

Coffee break

11:10 - 11:45

Francisco Melo
TBC

11:45 - 12:20

Enrique Merino
TBC

12:20 - 12:55

Silvio Tosatto
What is a repeat?

12:55 - 13:00

Wrap-up

Registration

Participation is free of charge, but all interested audience is kindly requested to register by contacting: refract@ngp-net.bio.unipd.it
Deadline for registration: 25 September 2022

Travel and venue

The hackathon and Supervisory Board meeting will be held at the Interdepartmental Complex A. Vallisneri, University of Padova (Via Ugo Bassi, 58/B - 35131 Padova, Italy)

The Conference will be held at the Aula Magna Lepschy, Department of Information Engineering, University of Padova (Via Gradenigo 6/B - 35131 Padova, Italy)

Participants arriving from the airport (Venice VCE or TSF) can reach the venue:

• via public transportation BUSITALIA (tickets on board 10€)
• via private shuttle AirService

Information and inquiry: refract@ngp-net.bio.unipd.it